From Interstate 40 East: Take I-40 east to Asheville. Take exit 50 (US Highway 25), then turn left at the traffic light after exiting. Stay in the left lane and follow signs to the Biltmore entrance.
From Interstate 40 West: Take I-40 west to Asheville and take exit 50B (US Highway 25 North). After exiting, stay in the left lane and follow signs to the Biltmore entrance.
From Interstate 26/U.S. Highway 19/23 East: Take I-26 east to Asheville. In Asheville, take I-240 east to I-40 west. Follow Interstate 40 west to exit 50B (US Highway 25 North). After exiting, stay in the left lane and follow signs to the Biltmore entrance.
From Interstate 26 West: Follow I-26 west towards Asheville to exit 31A (Hickory/Knoxville exit). Take I-40 east to exit 50 (US Highway 25), then turn left at the traffic light after exiting. Stay in the left lane and follow signs to the Biltmore entrance.
From the Blue Ridge Parkway: Take the U.S. Highway 25 North exit; Biltmore is approximately 4 miles from the parkway.